Global Healthcare Analyst

Tina Banerjee

Equity Bottom-Up

<ul>
<li>
<a href="https://www.smartkarma.com/entities/green-cross-corp" target="_blank" data-smartkarma-citation="entities:2969:1" rel="noopener">Green Cross (006280 KS)</a> is currently waiting for marketing approval from the FDA for its immune globulin intravenous injection, which will mark its entry into the U.S. market.</li>
<li>The company will start commercializing its hemophilia A treatment, GreenGene F in China market this year. As a third-generation product, GreenGene is expected to gain substantial market share.</li>
<li>Green Cross shares remained subdued last year, as the company could not finalize a contract manufacturing deal for COVID-19 vaccine.</li>
</ul>



Green Cross (006280 KS) is currently waiting for marketing approval from the FDA for its immune globulin intravenous injection, which will mark its entry into the U.S. market.
The company will start commercializing its hemophilia A treatment, GreenGene F in China market this year. As a third-generation product, GreenGene is expected to gain substantial market share.
Green Cross shares remained subdued last year, as the company could not finalize a contract manufacturing deal for COVID-19 vaccine.


Green Cross (006280 KS): Look Ahead for Key Milestones Amid Covid Vaccine Related Setback

Korea / Special Sits, Pairs, Index Rebalancing, Clepsydra Capital

Sanghyun Park

Korea / Special Sits, Pairs, Index Rebalancing

Clepsydra Capital

Investigate special situations, pairs, and index rebalancing trades in Korea.

Event-Driven

<ul>
<li>These indices use the GICS for classification. <strong>Bio and Internet are very straightforward. But qualitative judgment may be involved in Battery and Game.</strong>
</li>
<li>The passive impact of SoulBrain is estimated to be the largest, and LG Chem wouldn't be negligible either.</li>
<li>If AfreecaTV and Douzon Bizon are swapped, they will experience an impact of +2.0x ADTV and -5.0x ADTV. So they will shine the most if the swap takes place.</li>
</ul>


These indices use the GICS for classification. Bio and Internet are very straightforward. But qualitative judgment may be involved in Battery and Game.

The passive impact of SoulBrain is estimated to be the largest, and LG Chem wouldn't be negligible either.
If AfreecaTV and Douzon Bizon are swapped, they will experience an impact of +2.0x ADTV and -5.0x ADTV. So they will shine the most if the swap takes place.


KRX K-New Deal Index Rebalancing: Detailed Methodology & Changes Preview

Pan-Asia Index Rebalances/ Events/ Delta One, Periscope Analytics

Brian Freitas

Pan-Asia Index Rebalances/ Events/ Delta One

<ul>
<li>The review period for the March rebalance ends on 31 January, the announcement of the changes will be end February/beginning March, implementation will be at the close on 10 March.</li>
<li>
<a href="https://www.smartkarma.com/entities/lg-energy-solution" target="_blank" data-smartkarma-citation="entities:33464:1" rel="noopener">LG Energy Solution (LGENERGY KS)</a> will be included in the Battery index, and there will be other changes to the Bio, Internet, Game and BBIG indices.</li>
<li>The largest selling is expected to be on <a href="https://www.smartkarma.com/entities/douzone-bizon-co-ltd" target="_blank" data-smartkarma-citation="entities:20161:1" rel="noopener">Douzone Bizon (012510 KS)</a> due to a potential downweight in the Internet index and a deletion from the BBIG index.</li>
</ul>


The review period for the March rebalance ends on 31 January, the announcement of the changes will be end February/beginning March, implementation will be at the close on 10 March.

LG Energy Solution (LGENERGY KS) will be included in the Battery index, and there will be other changes to the Bio, Internet, Game and BBIG indices.
The largest selling is expected to be on Douzone Bizon (012510 KS) due to a potential downweight in the Internet index and a deletion from the BBIG index.


KRX BBIG Index Rebalance Preview (March): LG Energy Should Be Added; Plus Other Changes

<ul>
<li>
<a href="https://www.smartkarma.com/entities/yuhan-corp" target="_blank" data-smartkarma-citation="entities:10745:1" rel="noopener">Yuhan Corp (000100 KS)'s</a> R&amp;D investments have started contributing to revenue through outlicensing deals. The company signed five out-licensing deals totaling KRW 4 trillion over the past three years.</li>
<li>The company has launched one in-house developed oncology drug, lazertinib in Korea market this year. Other in-licensed marketed prescription drugs hold leadership positioning in their respective therapeutic areas.</li>
<li>Outlicesing partner Janssen is expected to file new drug application to the US FDA in 2022. Yuhan is entitled for double-digit royalty on commercialization of Lazertinib in global market.</li>
</ul>



Yuhan Corp (000100 KS)'s R&amp;D investments have started contributing to revenue through outlicensing deals. The company signed five out-licensing deals totaling KRW 4 trillion over the past three years.
The company has launched one in-house developed oncology drug, lazertinib in Korea market this year. Other in-licensed marketed prescription drugs hold leadership positioning in their respective therapeutic areas.
Outlicesing partner Janssen is expected to file new drug application to the US FDA in 2022. Yuhan is entitled for double-digit royalty on commercialization of Lazertinib in global market.


Yuhan Corp (000100 KS): R&D Endeavors Finally Began to Pay Back; Lazertinib to Drive Future Growth

KRX BBIG IndexThe KRX BBIG K-New Deal Index contains 12 stocks, listed either on the KOSPI or KOSDAQ market, three leading companies in each of the four industries. Each of the four industries also has its own index containing 10 constituents. So, we have one mother index (BBIG) and four sub-indices representing each of the four industries.
Secondary Battery

Bio

Internet

Game
Rebalancing: The top-three largest full market cap stocks from the Secondary Battery, Bio, Internet, and Game are selected for rebalancing in March and September. It is biannually reconstituted. Rebalancing occurs on the trading day following the last trading day of the March and September delivery month for KOSPI 200 futures contracts.





Rebalancing schedule

Rebalancing cycle
Semi-annually


Rebalancing month
March and September


Implementation date
The trading day following the last trading day for KOSPI 200 futures contracts


Next implementation date
September 10, 2021


Rebalancing trading
At the close on September 9, 2021


Screening base date
The last trading day of the month preceding the date of regular rebalancing


Screening period
The three months preceding the screening base date

Source: KRX &amp; WISE Index

Index weight: The BBIG Index is an equal-weight index in which each index constituent is allocated the same weight (8.33%) at each rebalancing. As for the four sub-indices, the top-three largest full market cap stocks are given the weight of 75%, in which each stock is allocated the same weight of 25% at each rebalancing. In contrast, the remaining seven constituents are given the remaining weight of 25%, where their float-adjusted market cap weights them.







Index calculations
BBIG
Four sub-indices


Number of constituents
12
10


Index weight
Equal-weighted at 8.33%

Top 3 (by full market cap): Equal-weighted at 25% The remaining 7: float-adjusted market cap-weighted totaling 25%



Source: KRX &amp; WISE Index

The mother index and battery sub-index have an AUM that is not small considering the number of constituents. BBIG has an AUM of ₩520B as of today, and its battery is ₩760B. Bio is about ₩100B. However, Internet and Game do not have meaningful AUMs.








ETFs tracking BBIG indices
Index
Ticker
AUM


Mirae Asset TIGER KRX BBIG K-New Deal ETF
BBIG
364960
₩480.9B


Hana Financial Investment Hana KRX BBIG K-New Deal ETN 3
700003
₩10.5B


TIMEFOLIO TIMEFOLIO BBIG Active ETF
385710
₩26.9B


- Total
-
₩518.3B


Mirae Asset TIGER KRX Second Battery K-NewDeal ETF
Secondary Battery
364980
₩759.7B


Mirae Asset TIGER KRX BIO K-New Deal ETF
Bio
364970
₩97.6B


Mirae Asset TIGER KRX Internet K-New Deal ETF
Internet
365000
₩49.2B


Mirae Asset TIGER KRX Game K-New Deal ETF
Game
364990
₩35.7B

Source: KRX

The screening period is the three months preceding the screening base date. So, the screening period this time is June 1 to August 31. Below is the daily average market cap from June 1 to July 19 and the index weight as of July 19.








BBIG
Weight, as of July 19
Average daily full market cap (June 1~July 19)
30-day average daily trade value


Kakao Corp
12.34%
₩66,478.6B
₩846.3B


Kakao Games Corp
11.59%
₩4,805.8B
₩244.2B


Naver Corp
8.96%
₩65,954.1B
₩388.6B


Samsung Biologics Co Ltd
9.13%
₩56,359.3B
₩77.4B


Samsung SDI Co Ltd
8.15%
₩46,995.6B
₩216.7B


Netmarble Corp
8.18%
₩11,730.2B
₩52.7B


SK Biopharmaceuticals
7.70%
₩9,681.8B
₩55.4B


SK Innovation Co Ltd
7.38%
₩25,451.8B
₩256.9B


LG Chem Ltd
7.11%
₩58,759.0B
₩197.2B


Celltrion, Inc.
6.61%
₩33,438.9B
₩149.8B


Douzone Bizon Co Ltd
6.22%
₩2,600.1B
₩21.1B


NCSoft Corp
6.57%
₩18,199.9B
₩70.1B

Source: KRX &amp; TIGER ETF











Sub-indices
Weight, as of July 19
Average daily full market cap (June 1~July 19
Float-adjusted market cap
30-day average daily trade value

Battery

LG Chem Ltd
21.89%
₩58,759.0B
₩38,763.3B
₩197.2B


Samsung SDI Co Ltd
25.07%
₩46,995.6B
₩34,335.0B
₩216.7B


SK Innovation Co Ltd
22.75%
₩25,451.8B
₩14,161.4B
₩256.9B


Posco Chemical Co Ltd
8.25%
₩9,112.5B
₩3,413.5B
₩63.8B


SKC Co Ltd
6.00%
₩5,640.2B
₩3,014.7B
₩57.0B


Ecopro BM Co Ltd
5.13%
₩4,604.0B
₩3,037.2B
₩71.4B


Iljin Materials Co Ltd
2.93%
₩3,269.7B
₩1,518.1B
₩24.5B


L&amp;F Co., Ltd.
3.52%
₩2,639.3B
₩1,564.8B
₩75.3B


SoulBrain Co Ltd
2.49%
₩2,539.3B
₩1,358.8B
₩10.2B


Chunbo Co Ltd
1.87%
₩1,929.2B
₩799.1B
₩30.8B

Bio

Samsung Biologics Co Ltd
29.94%
₩56,359.3B
₩13,954.6B
₩77.4B


Celltrion, Inc.
21.64%
₩37,030.6B
₩28,069.2B
₩149.8B


Celltrion HealthCare Co Ltd
10.06%
₩18,089.2B
₩10,956.6B
₩91.0B


SK Biopharmaceuticals Co Ltd
25.20%
₩9,681.8B
₩3,291.8B
₩55.4B


Celltrion Pharm Inc
2.35%
₩5,629.5B
₩2,512.4B
₩76.2B


Hanmi Science Co Ltd
1.56%
₩5,073.4B
₩1,610.3B
₩34.6B


Yuhan Corp
3.00%
₩4,454.7B
₩3,331.2B
₩14.6B


Shinpoong Pharmaceutical Co Ltd
2.07%
₩3,919.5B
₩2,390.5B
₩395.7B


Green Cross Corp
1.61%
₩3,808.6B
₩1,754.3B
₩23.1B


Seegene Inc
2.53%
₩3,927.5B
₩2,664.4B
₩289.6B

Internet

Kakao Corp
34.95%
₩66,478.6B
₩48,502.8B
₩846.3B


Naver Corp
25.47%
₩65,954.1B
₩53,106.2B
₩388.6B


Douzone Bizon Co Ltd
17.72%
₩2,600.1B
₩1,613.4B
₩21.1B


KMW Co Ltd
6.08%
₩2,144.3B
₩1,353.5B
₩13.0B


NHN KCP Corp
3.21%
₩1,365.8B
₩730.7B
₩9.5B


AfreecaTV Co Ltd
4.68%
₩1,294.1B
₩891.0B
₩16.8B


Ace Technologies Corp.
2.45%
₩786.2B
₩600.2B
₩11.5B


Seojin System Co Ltd
2.31%
₩811.4B
₩544.8B
₩11.1B


Ahnlab Inc
1.77%
₩703.2B
₩409.1B
₩7.2B


Rsupport Co Ltd
1.34%
₩497.3B
₩261.1B
₩29.1B

Game

NCSoft Corp
18.73%
₩18,199.9B
₩7,753.2B
₩70.1B


Netmarble Corp
23.34%
₩11,730.2B
₩3,657.5B
₩52.7B


PearlAbyss Corp
9.46%
₩4,587.3B
₩3,755.6B
₩45.2B


Kakao Games Corp
33.10%
₩4,805.8B
₩2,047.3B
₩244.2B


Com2uS Corp
3.91%
₩1,627.3B
₩1,022.8B
₩19.8B


NHN Corp
3.08%
₩1,552.2B
₩708.1B
₩9.6B


Doubleu Games Co Ltd
2.06%
₩1,160.4B
₩567.4B
₩7.6B


Webzen Inc
2.48%
₩1,094.4B
₩641.6B
₩9.5B


Wemade Co Ltd
2.00%
₩949.2B
₩505.4B
₩16.0B


Neptune Co
1.76%
₩815.4B
₩420.4B
₩6.5B

Source: KRX &amp; TIGER ETF



KRX BBIG Rebalancing Complete Preview: SK Bioscience, SK IE Tech, Krafton, Kakao Games, & Kakao Pay

South Korea

Medy-Tox Inc. is a biopharmaceutical company.  The Company researches, develops and manufactures biopharmaceutical products using clostridium botulinum which is a microorganism toxin.

Seegene, Inc. manufactures In Vitro Diagnostic (IVD) products mainly through molecular diagnostic method.  The Company provides diagnostic & screening products for cancer, sepsis, influenza and virus infection.

BIONEER Corp. provides molecular biology products & services.  The Company's product includes oligo synthesis, nucleic acid amplication and purification kits, and instruments for detecting biowarfare agents.

Green Cross Holdings Corporation is a holding company, which operates pharmaceutical, biotechnology, distribution system, life insurance, and healthcare entities.  The Company also invests in biotechnology venture capital and markets medical research information.

SillaJen, Inc. provides medical research and development services. The Company researches and develops treatment of cancer based on genetic recombination virus. SillaJen conducts its business in South Korea and the United States.

Hugel, Inc. is a Bio-pharmaceutical company that focuses on developing beauty/cosmetics related products.  The Company's main products include botulinum toxin and fillers.

Eubiologics Co. Ltd. researches and develops biopharmaceuticals. The Company offers bacterial vaccines for new epidemics and antibiotic resistance. Eubiologics operates in South Korea.

Genexine Co., Ltd. is bio technology company. The Company specialize in the development of therapeutic vaccines and next generation antibody fusion protein medications.

Pharmicell Co.,Ltd. is a Biotechnology company.  The Company's business area inlcudes stem cell therapeutics, Stem cell banking, Bio-based business and Cosmetics.

Amicogen, Inc. develops, produces and markets specialty enzymes and functional food ingredients. The Company offers special biocatalysts,  enzyme-based new functional materials, health foods, and consumer products.

Shanghai Haohai Biological Technology Company Limited manufactures absorbable biomedical materials. The Company targets therapeutic areas such as orthopedics, anti-adhesion and hemostasis, ophthalmology, and wound care and tissue filling.

Shanghai Haohai Biological Technology (6826 HK)

Zhongyuan Union Cell & Gene Engineering Corp Ltd, mainly operates in the stem cell inspection and storage business and other stem cell related business.

Zhongyuan Union Cell & Gene Eng Corp (600645 CH)

Beijing SL Pharmaceutical Co., Ltd. develops, manufactures and markets genetic engineering drugs, biological drugs, chemical drugs and medicine preparations.

Da An Gene Company Limited of Sun Yat-Sen University researches, develops, manufactures, and sells fluorescence Polymerase Chain Reaction (PCR) diagnostic kits and related medical equipment.  The Company's products are used in diagnosing Hepatitis B virus, Hepatitis C virus, Mycobacterium tuberculosis, chlamydia trachomatis, and SARS coronavirus.

OPKO Health, Inc. is involved in the discovery, development, and commercialization of pharmaceutical products, vaccines, and diagnostic products.

Jinyu Bio-Technology Co Ltd manufactures and markets biopharmaceuticals for animals and cashmere products.  The Company also produces linseed oil and invests in real estate development business.

Jinyu Bio-Technology Co., Ltd. (600201 CH)

Xencor, Inc. develops antibody and protein therapeutics to treat cancer and autoimmune inflammation. The Company markets its products to healthcare providers and facilities throughout the United States and internationally.

Chengzhi Company Limited manufactures and sells household chemical products, biotechnology products, pharmaceuticals, and information technology products. The Company's products include detergents, toothpastes, D-ribose, L-glutamine, Chinese traditional medicines, computer memory devices, and other related products.

PolyNovo Limited is a biotechnology company. The Company has a portfolio of biodegradeable polymers that have potential for application across numerous medical fields.

Ironwood Pharmaceuticals, Inc. is a pharmaceutical company. The Company discovers, develops, manufactures, and commercializes marketed drugs.   Ironwood products used in treatments of cholesterol, gastrointestinal and cardiovascular diseases, pain, inflammation, and others.

Green Cross Corporation manufactures household medical drugs. The Company's product includes medicines for cold and fever, nutrition, antiseptic drug, and a lip balm.

Price Gauge
52-week Range	0.00 - 0.00
Market Cap (USDm)	0.00
P/E	0.00
Dividend (Yield)	0.00

Green Cross (006280 KS)

KRX K-New Deal Index Rebalancing: Detailed Methodology & Changes Preview

This post details the full methodology of the KRX K-New Deal Index Rebalancing and previews likely changes in the upcoming rebalancing.

Sanghyun Park

KRX BBIG Index Rebalance Preview (March): LG Energy Should Be Added; Plus Other Changes

LG Energy should be added to the Secondary Battery and BBIG indices. There are changes to the Bio, Internet and Game indices too. Douzone Bizon...

Brian Freitas

Yuhan Corp (000100 KS): R&D Endeavors Finally Began to Pay Back; Lazertinib to Drive Future Growth

R&D investment is generating highest-margin earning outlicensing revenue stream. In-house developed drug, lazertinib is the biggest growth engine...

Tina Banerjee

KRX BBIG Rebalancing Complete Preview: SK Bioscience, SK IE Tech, Krafton, Kakao Games, & Kakao Pay

This post is a complete preview of the KRX BBIG rebalancing, featuring SK Bioscience, SK IE Technology, Kakao Games, Krafton, Kakao Pay, SD...

Sanghyun Park

Price Gauge

52-week Range

Market Cap (USDm)

P/E

Dividend (Yield)